cleavage – Communicable Diseases Research

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2

Article

Published on 2022-12-012022-11-16
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 변종,

[키워드] change changes in Characteristics circulating cleavage contribute contributing to demonstrated dependent on determinant endosomal entry endosomal entry pathway endosomal pathway Entry facilitate feature Fusogenicity H655Y identify increase investigated less Mutation omicron Omicron BA.1 and BA.2 Pathogenesis pathogenicity plasma membrane predominant Proteases recent reduce reduced retained SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 WT serine protease spike spike mutation Spike protein spike protein cleavage. subsequent the spike protein TMPRSS2 transmembrane serine protease Virological virus entry
[DOI] 10.1080/22221751.2022.2117098 PMC 바로가기

Label-free Sensing of Main Protease Activity of SARS-CoV-2 with an Aerolysin Nanopore

Article

Published on 2022-11-022022-11-15
Journal: Chemistry, an Asian journal
[Category] SARS, 치료기술,

Repurposing of HIV/HCV protease inhibitors against SARS-CoV-2 3CLpro

Article

Published on 2022-11-012022-11-15
Journal: Antiviral Research
[Category] SARS, 변종, 신약개발, 치료제,

Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease Variants

Article

Published on 2022-10-302022-11-16
Journal: Journal of Molecular Biology
[Category] COVID19(2023년), SARS, 변종,

[키워드] Affect analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type
[DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기

Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways

Article

Published on 2022-10-152022-11-16
Journal: Nature Communications
[Category] COVID19(2023년), SARS, 변종,

The Spike-Stabilizing D614G Mutation Interacts with S1/S2 Cleavage Site Mutations To Promote the Infectious Potential of SARS-CoV-2 Variants

Article

Published on 2022-10-122022-11-16
Journal: Journal of Virology
[Category] COVID19(2023년), SARS, 변종,

[키워드] acute respiratory syndrome addition association carried Cell cleavage cleavage site cleaved coronavirus D614G D614G mutation Delta dependent on epistasis epistatic interaction evaluate expressing expression increasingly Mutation omicron pandemic pathogenic Potential Protein proteolytic proteolytic cleavage pseudovirions pseudovirus pseudoviruses remained resulting S1 subunit S1/S2 S1/S2 cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 variant Site spike spike mutation spikes Spread stabilizing effect successive wave Transmissibility variant variants variants of concern variants. Viral particles viral spike viral variant virions wild-type Wuhan
[DOI] 10.1128/jvi.01301-22 PMC 바로가기

Intranasal administration of cold-adapted live-attenuated SARS-CoV-2 candidate vaccine confers protection against SARS-CoV-2

Article

Published on 2022-10-022022-11-15
Journal: Virus research
[Category] COVID19(2023년), SARS, 진단,

SARS-CoV-2 requires acidic pH to infect cells

Article

Published on 2022-09-202022-11-15
Journal: Proceedings of the National Academy of Sciences of
[Category] SARS, 치료기술, 치료제,

Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro

Article

Published on 2022-09-082022-11-15
Journal: Nature Communications
[Category] SARS, 진단, 치료제,

IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike

Article

Published on 2022-09-052022-11-16
Journal: Frontiers in Immunology
[Category] SARS, 유전자 메커니즘,